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Fitness

Training Around Injury: Maximizing Progress While Minimizing Risk

When it comes to fitness and exercise, injuries can be a major setback. Whether you’re an athlete, a fitness enthusiast, or simply someone trying to stay active, dealing with an injury can be frustrating and discouraging. However, it doesn’t mean that you have to stop training altogether. In fact, training around an injury can be an effective way to maintain progress and even aid in the recovery process.

In this comprehensive guide, we will explore various strategies, tips, and techniques for training around injury. From understanding the importance of rest and recovery to modifying your workouts and seeking professional guidance, we will cover it all. So, let’s dive in and learn how to maximize progress while minimizing the risk of further injury.

Training Around Injury: Key Considerations

Before we delve into the specifics of training around injury, it’s essential to understand some key considerations. These factors will help you approach your training regimen with caution, ensuring that you prioritize your health and well-being.

Listening to Your Body

One of the most important aspects of training around injury is learning to listen to your body. Pain and discomfort are signals that something isn’t right, and pushing through them can exacerbate the injury. Pay close attention to how your body feels during and after workouts, and be willing to modify or stop activities if necessary.

Consulting a Healthcare Professional

While this article provides valuable insights, it’s important to note that every injury is unique. Consulting a healthcare professional, such as a physical therapist or sports medicine doctor, is crucial for receiving personalized advice and guidance. They can assess your injury, provide appropriate recommendations, and monitor your progress.

Balancing Rest and Activity

Rest and recovery play a crucial role in the healing process. It’s essential to strike a balance between giving your body the rest it needs and engaging in appropriate levels of activity. Too much rest can lead to muscle atrophy and decreased mobility, while too much activity can hinder the healing process. Finding the right balance is key.

Gradual Progression

When training around an injury, it’s important to progress gradually. Avoid jumping back into intense workouts or pushing yourself too hard, too soon. Gradually increase the intensity, duration, and frequency of your workouts as your body allows. This approach will help prevent setbacks and promote steady progress.

Modifying Your Workouts

One of the primary challenges of training around injury is modifying your workouts to accommodate the injury while still making progress. Here are some effective strategies to consider:

1. Focus on Non-Impacted Areas

If one part of your body is injured, consider shifting your focus to non-impacted areas. For example, if you have a shoulder injury, you can focus on leg exercises or core workouts that don’t put strain on your shoulder joint. This way, you can continue training without aggravating the injury.

2. Incorporate Low-Impact Exercises

Low-impact exercises are gentle on the joints and can be an excellent option when training around injury. Activities such as swimming, cycling, or using an elliptical machine can provide cardiovascular benefits without putting excessive stress on the injured area.

3. Modify Range of Motion

Adapting the range of motion is another effective strategy. By reducing the range of motion in exercises, you can still engage the muscles without placing undue stress on the injured joint. For instance, if you have a knee injury, performing partial squats can be a safer alternative to full squats.

4. Use Resistance Bands or Light Weights

Incorporating resistance bands or light weights can be beneficial when training around injury. They provide resistance without overloading the injured area. Resistance band exercises and light dumbbell movements can help maintain muscle strength and mobility while minimizing the risk of aggravating the injury.

5. Focus on Stability and Balance

Injuries often disrupt the body’s balance and stability. Incorporating exercises that target these aspects, such as single-leg balances or stability ball exercises, can aid in the recovery process. By improving stability and balance, you enhance overall body control and reduce the risk of future injuries.

FAQs (Frequently Asked Questions)

FAQ 1: Can I continue training with a minor injury?

Yes, in many cases, training with a minor injury is possible. However, it’s crucial to consult a healthcare professional to determine the severity of the injury and receive appropriate guidance. They can help you modify your training regimen to ensure that you don’t exacerbate the injury.

FAQ 2: How long should I rest after an injury?

The duration of rest after an injury depends on various factors, including the type and severity of the injury. It’s essential to follow the recommendations of your healthcare professional. They will provide specific guidelines on rest periods and gradually reintroducing activity to promote healing.

FAQ 3: Can training around injury slow down the recovery process?

When done correctly, training around injury can actually aid in the recovery process. It promotes blood flow, maintains muscle strength, and helps preserve joint mobility. However, it’s crucial to follow the guidance of healthcare professionals and avoid activities that may further aggravate the injury.

FAQ 4: Should I use pain medication before training with an injury?

Using pain medication before training is not recommended. Pain medication can mask pain signals, potentially leading to further injury. It’s important to address the root cause of the pain and modify your training regimen accordingly. Consult your healthcare professional for appropriate pain management strategies.

FAQ 5: How can I prevent injuries during training?

Preventing injuries is crucial for long-term progress and overall well-being. Some preventive measures include warming up adequately before workouts, using proper form and technique, wearing appropriate protective gear, and gradually increasing the intensity of your workouts. Additionally, listening to your body and avoiding overtraining can help minimize the risk of injuries.

FAQ 6: Is it necessary to work with a personal trainer when training around injury?

While working with a personal trainer is not always necessary, it can be highly beneficial, especially when dealing with injuries. A qualified trainer can help design a customized training program tailored to your specific needs and limitations. They can provide guidance, monitor your progress, and ensure that you train safely and effectively.

Final Thoughts

Training around injury requires a cautious and thoughtful approach. By listening to your body, seeking professional guidance, and modifying your workouts, you can continue making progress while minimizing the risk of further injury. Remember to prioritize rest and recovery, gradually progress your training, and focus on exercises that don’t aggravate the injured area. Training around injury is a testament to your resilience and commitment to your fitness journey. Embrace the process, stay positive, and consult with professionals along the way.

Motivation

Being Mindful Helps Better Your Life

Welcome to our comprehensive guide on how being mindful can significantly improve and transform your life. In this article, we will delve into the power of mindfulness and its profound impact on various aspects of our well-being. By adopting mindfulness practices, you can cultivate a more present, fulfilling, and enriched life. Let’s explore the remarkable benefits of incorporating mindfulness into your daily routine.

Understanding Mindfulness

Mindfulness is the practice of intentionally focusing on the present moment without judgment. It involves developing an awareness of your thoughts, emotions, and sensations, while acknowledging and accepting them without attaching any value or criticism. By practicing mindfulness, you can detach from the past and future, allowing yourself to fully engage with the present experience.

The Benefits of Mindfulness

1. Improved Mental Health

Practicing mindfulness has been scientifically proven to enhance mental well-being. By cultivating a non-judgmental awareness of your thoughts and emotions, you can reduce stress, anxiety, and depression. Mindfulness empowers you to observe negative patterns of thinking and shift your perspective, fostering a greater sense of calm, clarity, and resilience.

2. Enhanced Physical Health

Mindfulness not only positively impacts your mental state but also contributes to improved physical health. Regular mindfulness practice can reduce blood pressure, strengthen the immune system, and alleviate chronic pain. By being fully present in each moment, you can make conscious choices that promote better overall health and well-being.

3. Heightened Productivity and Focus

In today’s fast-paced world, distractions abound, hindering our ability to concentrate. However, mindfulness allows us to develop laser-like focus and harness our productivity. By training our minds to remain fully present, we can engage more deeply in tasks, complete them efficiently, and achieve greater levels of success.

4. Enhanced Relationships

Mindfulness not only benefits individual well-being but also strengthens our connections with others. By practicing mindful listening and non-judgmental presence, we can cultivate deeper empathy, understanding, and compassion. This fosters more meaningful and harmonious relationships, both personally and professionally.

Incorporating Mindfulness into Your Daily Life

1. Mindful Breathing

Begin by focusing on your breath, observing its natural rhythm and flow. Take deep, intentional breaths, and allow yourself to be fully present in each inhale and exhale. This simple practice can anchor you in the present moment and help you cultivate a sense of calm.

2. Mindful Eating

Engage all your senses while eating. Slow down and savor each bite, paying attention to the flavors, textures, and smells. By practicing mindful eating, you can develop a healthier relationship with food, listen to your body’s cues, and make more conscious choices.

3. Mindful Movement

Engage in physical activities mindfully, such as yoga, walking, or dancing. Pay attention to the sensations in your body, the rhythm of your movements, and the connection between your body and mind. This practice fosters a deeper appreciation for your body and enhances overall well-being.

4. Mindful Technology Use

In an increasingly digital world, it’s crucial to bring mindfulness to our technology usage. Set boundaries, take breaks, and be fully present in the activities you engage in, whether it’s work or leisure. Mindful technology use can prevent digital overload and promote a healthier relationship with screens.

Final Thoughts

Incorporating mindfulness into your life can bring about transformative changes in your overall well-being. By practicing mindfulness in various aspects of your daily routine, you can experience improved mental health, enhanced physical well-being, increased productivity, and enriched relationships. Start your mindfulness journey today and unlock the incredible benefits it has to offer.

Technology & A.I

Longtime Amazon Web Services Executive Joins Google Cloud

In a surprising move, Chris Vonderhaar, a veteran executive at Amazon Web Services (AWS), has recently joined Google Cloud, one of AWS’s main competitors. Vonderhaar’s appointment as Vice President of Demand & Supply Management at Google Cloud marks a significant development in the company’s management team. This article will explore the details of this executive shakeup, Vonderhaar’s previous role at AWS, and the potential implications of his move to Google Cloud.

A Leadership Change at Google Cloud

According to CNBC, Google Cloud has undergone a significant restructuring of its management team, with the addition of Chris Vonderhaar as the Vice President of Demand & Supply Management. This change comes alongside another notable shift, as Urs Holzle, a prominent Google executive responsible for the company’s data center initiatives, transitions into an individual contributor role.

Chris Vonderhaar’s Background

Chris Vonderhaar had a remarkable career at Amazon, spanning an impressive 13 years. During his tenure, he played a pivotal role in overseeing the design and operation of Amazon Web Services’ extensive global network of data centers. Vonderhaar’s departure from Amazon was initially discovered when his name went missing from the internal corporate directory, leading to speculation within the industry about his future plans.

Amazon’s Non-Compete Agreements

Amazon has a reputation for actively enforcing non-compete agreements and pursuing legal action against former employees who join rival companies. These agreements aim to restrict or block executives from working for competitors. While California has essentially banned non-compete agreements, Washington state imposes certain provisions limiting their applicability, particularly for employees earning over $100,000 annually.

Vonderhaar’s Move to Google Cloud

Google Cloud’s hiring of Vonderhaar raises questions regarding potential constraints resulting from Amazon’s non-competition agreement. Despite this, Google did not address the issue directly when questioned about the matter. It remains to be seen how this transition will unfold and whether any legal disputes may arise between the two technology giants.

Amazon’s History of Lawsuits

Amazon has a history of taking legal action against executives who join Google Cloud after leaving AWS. Previous cases primarily involved individuals in marketing and sales roles. Notably, in 2012, a federal judge ruled in favor of a former AWS sales leader, allowing him to work for Google Cloud with minimal restrictions. Amazon has settled similar lawsuits in subsequent years, indicating their willingness to pursue legal avenues to protect their confidential information.

AWS’s Dominance in the Cloud Infrastructure Market

As of the first quarter of this year, Amazon Web Services maintains a leading position in the cloud infrastructure services market, surpassing both Microsoft and Google with a 32% market share, according to Synergy Research Group. However, Google Cloud has shown signs of growth, turning its first profit and increasing its market share by one percentage point during the same period.

Speculations and Ironies

There were speculations among industry insiders that Vonderhaar might have been a candidate for the top position at AWS when Andy Jassy assumed the role of Amazon CEO. However, the company ultimately appointed Adam Selipsky, the former CEO of Tableau Software, to lead its cloud business. Interestingly, the news of Vonderhaar’s employment at Google Cloud was initially disclosed on social media by Amy Nelson, the wife of former AWS real estate manager Carleton Nelson. Amy Nelson highlighted the irony of Vonderhaar joining a direct competitor to AWS, considering his involvement in a legal case where Amazon accused her husband of violating a non-competition agreement through data center real estate deals.

Conclusion

Chris Vonderhaar’s move from Amazon Web Services to Google Cloud represents a significant change in the competitive landscape of the cloud computing industry. While the implications of this shift are yet to fully unfold, it highlights the ongoing battle for talent and expertise in the tech sector. As Google Cloud continues to grow and challenge AWS’s dominance, Vonderhaar’s expertise and experience will likely contribute to shaping the future of cloud computing.

Revolutionizing Pediatric Care: Wavely Diagnostics Raises $1.35 Million to Develop Innovative Smartphone App

Transforming Pediatric Care with Advanced Technology

In an impressive stride towards revolutionizing pediatric care, University of Washington spinout Wavely Diagnostics has successfully raised $1.35 million. The Seattle-based company aims to combat the prevalent issue of ear infections in children through the development of a groundbreaking smartphone app. By utilizing acoustic signals and cutting-edge technology, Wavely’s diagnostic app can effectively detect early signs of ear infections with the simple placement of a paper funnel at the opening of the ear canal. This groundbreaking solution allows caregivers to connect with virtual care physicians, paving the way for a significant shift in pediatric care towards the virtual space.

The Innovation: Harnessing Acoustic Signals for Early Detection

Wavely’s diagnostic app relies on acoustic signals to identify the presence of an ear infection. By bouncing an acoustic sound wave off the eardrum, the app can capture its reflection, which is then analyzed using machine learning algorithms. This innovative approach enables the identification of fluid buildup in the middle ear, a common indicator of an ear infection. Led by co-founders Randall Bly, a distinguished pediatric ear, nose, and throat physician at Seattle Children’s Hospital, and Shyam Gollakota, a renowned professor of computer science and engineering at the University of Washington, Wavely has pioneered this cutting-edge technology.

Shifting Pediatric Care to the Virtual Space

CEO Arna Ionescu Stoll, during her appearance at the esteemed GeekWire Summit, expressed the company’s mission to transition pediatric care to the virtual realm. The app, showcased in the renowned “Inventions We Love” category, represents a significant leap forward in digital healthcare solutions. By enabling caregivers to promptly connect with virtual care physicians, Wavely empowers them to seek immediate medical advice when signs of a possible ear infection arise in children.

Funding for Future Growth and Expansion

Wavely Diagnostics recently secured $1.35 million in funding, which will be utilized to prepare for the anticipated public release of their app in app stores later this year. The company’s platform is presently undergoing pilot testing in collaboration with a prominent U.S. healthcare system. This new round of funding further bolsters Wavely’s total investor and grant funding to an impressive $6.35 million, which includes a previous $2.2 million seed funding round in February 2022 and a $1.8 million small business grant received in November from the National Institute on Minority Health and Health Disparities.

Trailblazing Co-founders: Expertise and Vision

Co-founders Randall Bly and Shyam Gollakota bring a wealth of expertise and a shared commitment to revolutionizing healthcare through technology. Dr. Bly, an esteemed pediatric ear, nose, and throat physician, has dedicated his career to improving the well-being of children. Meanwhile, Professor Gollakota’s pioneering research in computer science and engineering has paved the way for innovative breakthroughs in various fields. Together, they published a study that introduced the technology underpinning Wavely’s diagnostic app. Leveraging a smartphone’s microphone and speaker, their study successfully detected limited eardrum mobility resulting from fluid buildup in the middle ear.

Building on Success: Wavely’s Stellar Track Record

Wavely’s recent funding round was spearheaded by Robin Hood Ventures, with participation from esteemed previous investors including WRF Capital, Ambit Health Ventures, the WXR Fund, Wealthing, Healthtech Capital, and Princeton Alumni Angels. This diverse range of investors highlights the widespread recognition and enthusiasm surrounding Wavely’s groundbreaking technology. In conjunction with the funding, Sasha Schrode, a member of Robin Hood Ventures, has joined Wavely’s board of directors, further augmenting the company’s expertise and guidance.

Expanding Partnerships and Transforming Healthcare

With the successful funding round, Wavely is poised to capitalize on the significant interest from providers and payers across the United States. The company’s transformative digital health solution has garnered immense attention, and this funding will provide the necessary resources to establish and solidify partnerships. Wavely’s ultimate goal is to expedite the delivery of their groundbreaking technology to both healthcare providers and parents, facilitating enhanced virtual care for pediatric patients.

Pioneering a New Era in Pediatric Care

Wavely Diagnostics’ recent funding success and pioneering smartphone app highlight the remarkable potential of technology to revolutionize pediatric care. By harnessing acoustic signals and leveraging machine learning algorithms, Wavely’s app can detect early signs of ear infections, empowering caregivers to seek virtual medical assistance promptly. With their unwavering commitment to improving children’s health and well-being, Wavely’s team of experts is on a transformative journey towards redefining the future of pediatric care. As their innovative solution prepares for a public release later this year, the impact of their revolutionary technology is set to be felt across the healthcare industry and beyond.

Exploring the Promise of xAI: Elon Musk’s Visionary Leap into Artificial Intelligence

Unveiling xAI: The Pursuit of Understanding Reality

Elon Musk, the extraordinary mind behind Tesla and SpaceX, has once again taken the world by storm with the introduction of his latest venture into the realm of artificial intelligence (AI). Named xAI, this groundbreaking company aims to redefine our comprehension of reality itself. Musk, renowned for his audacious ambitions, hinted at the company’s grand mission through a tweet, intriguing the masses with a promise of unveiling the true nature of the universe.

A Stellar Team of AI Pioneers

Leading the charge at xAI is none other than Elon Musk himself, guiding a team of exceptional individuals who have left their mark on the AI landscape. These talented minds bring a wealth of experience from renowned institutions such as OpenAI, Google Research, Microsoft Research, and DeepMind (which recently merged with Google). Collaborating with Musk, the team at xAI comprises Igor Babuschkin, Manuel Kroiss, Yuhuai (Tony) Wu, Christian Szegedy, Jimmy Ba, Toby Pohlen, Ross Nordeen, Kyle Kosic, Greg Yang, Guodong Zhang, and Zihang Dai. Additionally, xAI benefits from the guidance of Dan Hendrycks, a distinguished researcher who currently leads the Center for AI Safety, a nonprofit organization dedicated to mitigating the societal-scale risks associated with AI.

Engaging with the xAI Team: Twitter Spaces Discussion

Excitement abounds as xAI invites enthusiasts to engage directly with its brilliant team members. On July 14th, xAI will be hosting a captivating Twitter Spaces discussion, providing an unparalleled opportunity for participants to meet the minds behind this groundbreaking endeavor. Attendees can pose questions, unraveling the mysteries and intricacies of xAI’s mission. While the specific timing of the event remains undisclosed, eager followers are anxiously awaiting the chance to interact with the brightest stars of xAI.

xCORP and xAI: A Harmonious Collaboration

xAI, while separate from Musk’s overarching xCORP entity, maintains a close relationship with other ventures under Musk’s leadership, including Tesla and X (Twitter). Musk, ever the vigilant guardian of his creations, recently implemented temporary restrictions on his Twitter activity. These measures were taken in response to concerns about data scraping by AI startups seeking valuable information for the development of large language models (LLMs).

The Genesis of xAI: An Ambitious Vision Takes Shape

Whispers of xAI first emerged in April when official filings revealed Musk’s involvement in the company’s formation in Nevada. Initial documents listed Musk as the director, with Jared Birchall, the director of Musk’s family office, serving as the secretary. While details about xAI were scarce at the time, reports suggested that Musk sought financial support from SpaceX and Tesla to lay the foundation for this groundbreaking venture.

A Departure from OpenAI: Musk’s Quest for Unconstrained Innovation

Musk’s foray into the realm of AI is not without precedent. In 2015, he co-founded OpenAI, an influential AI organization. However, in 2018, Musk made the difficult decision to distance himself from OpenAI to prevent potential conflicts of interest with Tesla, a company at the forefront of AI advancements. Since then, Musk has been vocal in his critique of OpenAI and has hinted at his involvement in developing “TruthGPT” during an interview with Tucker Carlson.

xAI: Pushing Boundaries and Shaping the Future

With xAI, Elon Musk continues his relentless pursuit of innovation and discovery, delving into the mysteries of the universe through the lens of artificial intelligence. As this extraordinary company embarks on its path, experts and enthusiasts alike eagerly anticipate the revolutionary breakthroughs and advancements that xAI will usher into the world. With Musk’s visionary leadership and an exceptional team at its helm, xAI stands poised to reshape our understanding of reality and illuminate the limitless potential of AI-driven exploration.

Sarah Silverman and Authors File Lawsuits Against AI Language Models

Comedian Sarah Silverman, along with two authors, has filed lawsuits against Meta and OpenAI, the creator of ChatGPT, alleging that their AI language models were trained using copyrighted materials from their books without their knowledge or consent.

The lawsuits were filed in a San Francisco federal court and are seeking class action status. Sarah Silverman, known for her book “The Bedwetter,” is joined by authors Christopher Golden and Richard Kadrey in filing the lawsuits.

AI tools have gained significant attention in recent months for their remarkable ability to generate written content and images based on user prompts. These tools rely on large language models trained on extensive online data. However, concerns have arisen that these models might be incorporating copyrighted works without permission, potentially jeopardizing the livelihoods of content creators.

The lawsuit against OpenAI alleges that ChatGPT generates summaries of the plaintiffs’ copyrighted works when prompted, which implies that ChatGPT was trained using their copyrighted materials. According to the complaint, the authors did not provide consent for their books to be used as training material for ChatGPT. Similarly, the lawsuit against Meta claims that the company used the plaintiffs’ copyrighted books to train LLaMA, Meta’s set of large language models released in February. The suit further asserts that Meta obtained much of the training material, including copyrighted works authored by the plaintiffs, without consent, credit, or compensation.

Additionally, the lawsuit against Meta suggests that the company accessed copyrighted books through an online “shadow library” website that contains a substantial amount of copyrighted material.

Both Meta and OpenAI have yet to comment on the lawsuit.

This legal action taken by Sarah Silverman follows a previous lawsuit against OpenAI, which accused the company of misappropriating individuals’ personal data from the internet to train its AI tools. (OpenAI has not responded to comments regarding the lawsuit.)

In May, OpenAI CEO Sam Altman acknowledged the need for more action to address concerns from creators regarding the usage of their works by AI systems. He stated, “We’re striving to develop new models where creators are compensated when an AI system utilizes their content or style.”

Charm AI To Decode Brain Tumor DNA

In a groundbreaking development, scientists have unveiled CHARM, an AI tool capable of swiftly unraveling the molecular identity of brain tumors during surgery. Traditionally, this process has taken several days or even weeks. However, with CHARM, neurosurgeons can now make critical decisions regarding tissue removal and on-the-spot treatments with real-time precision. While the tool still requires clinical validation and FDA approval, its development represents a significant leap forward in the field of oncology.

It is not just within the operating room that a tumor’s molecular type holds importance. Understanding this information can provide valuable insights into the tumor’s potential aggressiveness and its response to treatment.

Here are the key facts about CHARM:

CHARM is an AI tool designed to decode a brain tumor’s DNA during surgery, enabling real-time molecular diagnosis to guide surgical decisions.
Currently, the human eye struggles to detect subtle genomic variations in tissue slides. CHARM overcomes this limitation by offering an impressive 93% accuracy rate in identifying specific molecular mutations.
While initially developed for glioma, researchers believe that CHARM could be retrained to identify other subtypes of brain cancer, showcasing its versatility in cancer diagnosis.
Source: Harvard

The AI tool created by scientists has the ability to rapidly decipher a brain tumor’s DNA, determining its molecular identity during surgery. This is critical information that typically takes days or even weeks to obtain using the existing approach.

Neurosurgeons can utilize the knowledge of a tumor’s molecular type to make informed decisions while the patient is still on the operating table. These decisions include the amount of brain tissue to be removed and the administration of tumor-killing drugs directly into the brain. The report, published on July 7 in the journal Med and led by researchers from Harvard Medical School, sheds light on this significant development.

During surgery, an accurate molecular diagnosis that reveals DNA alterations in a cell helps the neurosurgeon determine the optimal amount of brain tissue to remove. Removing too much tissue when the tumor is less aggressive can impact the patient’s neurological and cognitive functions. Conversely, removing too little tissue when the tumor is highly aggressive may result in the presence of malignant tissue that can grow and spread rapidly.

Study senior author Kun-Hsing Yu, assistant professor of biomedical informatics in the Blavatnik Institute at HMS, explains, “Right now, even state-of-the-art clinical practice cannot profile tumors molecularly during surgery. Our tool overcomes this challenge by extracting thus-far untapped biomedical signals from frozen pathology slides.”

Knowing a tumor’s molecular identity during surgery is also invaluable because certain tumors benefit from on-the-spot treatment. In this case, drug-coated wafers can be placed directly into the brain at the time of the operation. This advancement in determining intraoperative molecular diagnosis in real time paves the way for the development of real-time precision oncology.

The current standard approach for intraoperative diagnosis involves taking brain tissue, freezing it, and examining it under a microscope. However, freezing the tissue alters the appearance of cells under the microscope, which can interfere with clinical evaluation accuracy. Additionally, even with the aid of powerful microscopes, the human eye cannot reliably detect subtle genomic variations on a slide.

The AI tool called CHARM (Cryosection Histopathology Assessment and Review Machine) addresses these challenges. CHARM is freely available for other researchers to use. However, it still needs clinical validation in real-world settings and FDA clearance before it can be deployed in hospitals, according to the research team.

Recent advancements in genomics have allowed pathologists to differentiate molecular signatures across various types of brain cancer and within specific types as well. Glioma, the most aggressive brain tumor and the most common form of brain cancer, has three main subvariants with different molecular markers and varying growth and spread tendencies.

CHARM’s ability to expedite molecular diagnosis is particularly beneficial in areas with limited access to technology for rapid cancer genetic sequencing.

Knowledge of a tumor’s molecular type not only aids decision-making during surgery but also provides insights into its behavior, aggressiveness, and likely response to treatments. This knowledge can inform post-operative decisions.

The new tool aligns with the World Health Organization’s recently updated classification system for diagnosing and grading the severity of gliomas. The system emphasizes the importance of diagnosing tumors based on their genomic profile.

To develop CHARM, researchers used 2,334 brain tumor samples from 1,524 individuals with glioma across three different patient populations. The tool achieved an impressive accuracy rate of 93% in identifying specific molecular mutations when tested on a set of brain samples that had never been seen before. Furthermore, it successfully classified three major types of gliomas, each with distinct molecular features, prognoses, and treatment responses.

Additionally, CHARM could capture visual characteristics of the tissue surrounding malignant cells, such as greater cellular density and increased cell death. These characteristics indicate more aggressive types of glioma. The tool also identified clinically significant molecular alterations in low-grade gliomas, a less aggressive subtype of glioma with different growth, spread, and treatment response tendencies.

CHARM’s algorithm connects the appearance of cells, such as the shape of their nuclei and the presence of edema around the cells, with the tumor’s molecular profile. This ability to assess the broader context around the image enhances the accuracy of the model, making it more similar to how a human pathologist visually assesses a tumor sample.

While CHARM was initially trained and tested on glioma samples, it can potentially be retrained to identify other subtypes of brain cancer. Developing AI models to profile different types of cancer, such as colon, lung, and breast, has already been achieved. However, gliomas have presented challenges due to their molecular complexity and the significant variation in the shape and appearance of tumor cells.

To maintain peak performance, the CHARM tool would need periodic retraining to accommodate new disease classifications that emerge with advancements in knowledge.

The coinvestigators of this work include MacLean P. Nasrallah, Junhan Zhao, Cheng Che Tsai, David Meredith, Eliana Marostica, Keith L. Ligon, and Jeffrey A. Golden.

The research received support from various sources, including the National Institute of General Medical Sciences grant R35GM142879, the Google Research Scholar Award, the Blavatnik Center for Computational Biomedicine Award, the Partners Innovation Discovery Grant, and the Schlager Family Award for Early-Stage Digital Health Innovations.

Crypto

ARK sells 135K Coinbase shares

On the 11th of July, ARK Invest, the investment firm helmed by Cathie Wood, gained attention for divesting 135,152 shares of Coinbase. This amounted to an approximate value of $12 million, constituting 0.14% of the total holdings in ARK Innovation ETF. Interestingly, this decision was made during a time when Coinbase’s stock price experienced a substantial surge, briefly surpassing $90 on July 11th. Despite the sale, the stock closed at $89 on that particular day.

Coinbase has recently demonstrated robust performance, with a remarkable surge of over 60% in the last month and an impressive year-to-date increase of more than 140%. It is noteworthy that this is not the first instance where Cathie Wood has capitalized on profits from Coinbase shares this year. On March 21st, ARK Invest sold 160,887 Coinbase shares from its ARK Fintech Innovation ETF.

While ARK Invest has been divesting some of its Coinbase shares, it has also been actively acquiring the stock across various ARK funds. In June alone, ARK Invest purchased Coinbase shares worth approximately $40 million. Prior to that, they acquired around $33 million worth of shares in April and May, as well as $117 million worth of shares in March.

It is important to mention that several executives of Coinbase, including CEO Brian Armstrong, have also been selling their shares amidst the recent surge in price. For instance, on July 6th, Armstrong and other senior executives collectively sold 88,058 shares, amounting to around $6.9 million at the time. Additionally, Coinbase’s chief accounting officer, Jennifer Jones, sold 74,375 shares on June 29th, resulting in a net gain of $5.2 million.

Interestingly, despite the ongoing lawsuit filed by the U.S. Securities and Exchange Commission against Coinbase regarding securities violations, the company’s stock price has continued its upward trajectory. One potential driving factor behind this growth is the market’s anticipation of the BlackRock spot Bitcoin ETF filing, where Coinbase has been designated as a “surveillance-sharing” partner.

Blockchain Association Calls for Investigation into Prometheum’s Regulatory Clarity

The group raised concerns over Prometheum’s changing position on crypto regulatory clarity and under what circumstances the firm obtained a special purpose broker-dealer license.

Advocacy Group Urges SEC Investigation into Prometheum

The United States-based crypto advocacy group, Blockchain Association, has submitted a letter to the Securities and Exchange Commission’s (SEC) Office of Inspector General, calling for an investigation into the crypto firm, Prometheum.

In a letter dated July 12, the Blockchain Association requested SEC Inspector General Deborah Jeffrey to look into the approval of Prometheum’s special purpose broker-dealer license (SPBD) by the Financial Industry Regulatory Authority (FINRA). The group also expressed concerns about the means through which co-CEO Aaron Kaplan obtained a seat to testify before the U.S. House Financial Services Committee in June.

Concerns Over Prometheum’s Special Purpose Broker-Dealer License

The advocacy group highlighted its concern over Prometheum’s ability to acquire an SPBD license in May 2023, given the ongoing uncertainty surrounding the application of U.S. securities laws to cryptocurrency firms. The Blockchain Association noted that Prometheum had altered its public stance on regulatory clarity from the SEC. In April 2021, they called for regulatory clarity, but later claimed that “there exists a clear pathway to registration for digital assets and legislation is unnecessary.”

The association expressed its concern that Prometheum may have received preferential treatment from the Commission in exchange for supporting the Commission’s policy goals or leveraging personal connections with the Commission to gain an unfair advantage in the market. They further questioned whether Chair Gensler was using Prometheum and the SPBD licensure process as a means to obstruct congressional efforts towards legislation by spreading the false narrative that the law is already clear regarding digital asset securities.

Advocacy Group Seeks Investigation through FOIA Request

The call for an investigation into Prometheum came after the advocacy group submitted a Freedom of Information Act (FOIA) request in June, seeking documents and communications related to the firm’s license. The Blockchain Association stated that it was still awaiting answers regarding the requested information.

Cointelegraph reached out to Prometheum co-CEO Aaron Kaplan for comment but did not receive a response at the time of publication. It is worth noting that several U.S. lawmakers have also called for investigations by the Department of Justice and SEC into Prometheum due to alleged ties to China-based firms, which appear unrelated to the allegations made by the Blockchain Association.

Final Thoughts

The Blockchain Association’s letter to the SEC’s Office of Inspector General raises significant concerns regarding Prometheum’s changing stance on regulatory clarity and the circumstances surrounding the acquisition of its special purpose broker-dealer license. The association’s call for an investigation seeks to ensure fair market practices and transparency within the crypto industry. As the industry continues to evolve, it is crucial for regulators and advocacy groups to work together in establishing a clear framework for the governance of digital assets and securities.

An Altcoin Project on Solana (SOL) Network Gains Momentum as Coinbase Announces Listing

In an exciting development for cryptocurrency enthusiasts, the leading US-based crypto exchange, Coinbase, recently revealed its plans to list an altcoin project on the Solana (SOL) network. This news has triggered a surge in the project’s value, causing it to rally significantly. In this article, we will delve into the details of this altcoin project and its implications for the cryptocurrency market.

Coinbase’s Announcement

Coinbase made a public announcement stating its intention to support Helium (HNT) on the Solana network. The company urged users to refrain from sending this digital asset over other networks to avoid the risk of losing their funds. Transfers for Helium are currently available on Coinbase in regions where trading is supported.

Trading of Helium on Coinbase is scheduled to commence on or after 9 am PT on July 12, 2023, provided that the liquidity conditions are met. The initial launch of the HNT-USD trading pairs will occur in phases, with full trading support dependent on the establishment of sufficient supply. However, it’s important to note that certain jurisdictions may have restrictions on trading Helium.

Soaring Value and Market Impact

The news of Coinbase’s listing has had an immediate impact on the value of Helium. Shortly after the announcement, the altcoin experienced a significant surge in price, reaching a high of $1.48 on Wednesday. At the time of writing, Helium is trading at $1.44, marking a 21% increase from its 14-day low of $1.19.

Understanding Helium

Helium operates as a decentralized network specifically designed for the Internet of Things (IoT). By leveraging smart contracts and enterprise applications, Helium enables IoT devices connected to the network to communicate and share data seamlessly. Participants in the network, including those who set up Helium hotspots, are rewarded with HNT tokens.

Coinbase’s Experimental Label

Coinbase has classified Helium as an “Experimental Label” asset, which indicates that it falls under the category of riskier, lower liquidity tokens. The exchange’s decision to support Helium reflects its commitment to offering a diverse range of assets to its users while recognizing the unique characteristics and potential of emerging altcoin projects.

Advantages of Helium

Helium aims to provide more efficient and cost-effective wireless coverage for IoT devices compared to traditional networks. By operating in a decentralized manner, it offers greater reliability and scalability. The project’s use of smart contracts and enterprise applications enhances the functionality of IoT devices, unlocking new possibilities for the Internet of Things ecosystem.

The announcement of Coinbase’s listing of Helium on the Solana network has generated significant excitement within the cryptocurrency community. As a project dedicated to revolutionizing the IoT space, Helium’s integration with Coinbase is expected to unlock new opportunities and increase its visibility in the market. It will be interesting to observe how Helium’s value evolves in response to its listing on Coinbase and how it contributes to the broader adoption of cryptocurrencies.

Top US-based Crypto Exchange Coinbase Launches Private Messaging Feature for Ethereum Addresses

Coinbase, one of the leading US-based cryptocurrency exchange platforms, is introducing an exciting new feature that allows private direct messaging between Ethereum (ETH) addresses. In a recent announcement, Coinbase revealed its plan to roll out a decentralized chat function for its wallet. This innovative feature, powered by the web3 chat protocol XMPT, aims to provide users with complete ownership of their chats and enhance their overall experience on the platform.

Connect and Own Your Chats

With the new chat feature on Coinbase Wallet, users can now connect with their communities in a whole new way. By leveraging this feature, users not only retain ownership of their digital assets but also gain control over their conversations. Coinbase emphasizes the importance of user privacy and security, assuring that they do not have access to the encrypted messages. Instead, the messages are end-to-end encrypted and securely stored within XMPT’s decentralized communication network.

Finding Connections Made Easy

Coinbase’s chat feature also includes a convenient search function, allowing users to find and connect with others seamlessly. Users can utilize a personalized QR code to share and invite friends to chat. Additionally, they can explore new connections by using the search feature. The integration of these functionalities enhances the overall social experience within the Coinbase ecosystem.

Interoperability and Portability

The messaging feature on Coinbase Wallet offers excellent interoperability. Users can import and export chat logs to other projects effortlessly. This means that users have the freedom to take their conversations to different platforms and social DApps (decentralized applications). It further empowers users by giving them control over their communication and the flexibility to engage with their preferred applications while keeping their chats intact.

Gas-Free Transactions with Polygon

Coinbase aims to provide its users with a seamless experience by reducing transaction costs. With the integration of Polygon (MATIC), a layer-2 scaling solution, users can now enjoy gas-free transfers of the stablecoin USD Coin (USDC). This feature simplifies the process of sending payments and enables instant transactions on Polygon. Users can send USDC to anyone, anywhere on Polygon, without incurring any gas fees within the Coinbase Wallet app.

Final Thoughts

Coinbase’s introduction of private messaging between Ethereum addresses marks a significant step forward in enhancing the user experience on the platform. By prioritizing user privacy, security, and ownership, Coinbase empowers its users to connect and communicate within a trusted and secure environment. The integration of interoperability and gas-free transactions further solidifies Coinbase’s commitment to providing an inclusive and cost-efficient ecosystem for cryptocurrency enthusiasts.

Despite the Exponential Growth of Threads, Twitter Remains Dominant in the Crypto Community

In recent times, Meta’s Twitter competitor, Threads, has experienced rapid growth, amassing over 100 million users within a week of its launch. However, despite this exponential growth, a significant portion of the crypto community remains loyal to Twitter. This article explores the reasons behind the crypto community’s hesitation to switch platforms and highlights Twitter’s continued dominance in the industry.

The Lukewarm Response to Threads

As reported by NFT Gators, a staggering 70% of the 117 major players in the crypto industry have yet to open a Threads account, even after a week of its launch. While the user base of Threads is growing at an unprecedented rate, the lukewarm response from the crypto community indicates a reluctance to abandon Twitter in favor of the new platform.

Twitter’s Influence on Crypto Enthusiasts

Twitter has long been the preferred platform for crypto enthusiasts, with dedicated subsets like ‘Crypto Twitter’ and ‘NFT Twitter.’ NFT Gators’ analysis shows that Twitter’s engagement in tweet volume, especially with popular hashtags like #Bitcoin and #Ethereum, is unmatched. On average, #Bitcoin generates around 563,000 tweets per week, while #Ethereum reaches approximately 268,000 tweets.

Engagement Levels on Threads vs. Twitter

According to NFT Gators, crypto brands that have established a presence on Threads experience relatively lower engagement levels compared to Twitter. For instance, the most followed crypto account on Threads, Binance Exchange, has accumulated over 335,000 followers. This number pales in comparison to Binance’s presence on Twitter, despite the exchange investing $500 million in Elon Musk’s Twitter takeover in October 2022.

The Crypto Community’s Reluctance to Adopt Threads

NFT Gators’ research findings indicate that out of the top 117 crypto brands, almost 70% have yet to open a Threads account. While Threads has achieved an impressive user base of over 100 million users, it still lags behind Twitter, which boasts an estimated 350 million users. Furthermore, Threads faces challenges such as being unavailable in mainland Europe due to concerns over EU data privacy legislation and the absence of a desktop version. These limitations may hinder its growth prospects within the crypto community.

Twitter’s Continued Dominance in the Web3 Industry

The cautious approach of the crypto community toward Threads underscores the entrenched influence and popularity of Twitter within the web3 industry. Despite Meta’s ambitious entry into the social media landscape, Twitter remains the go-to platform for crypto enthusiasts, industry leaders, and influencers.

Despite the exponential growth of Threads, a significant portion of the crypto community remains loyal to Twitter. The lukewarm response and cautious adoption of Threads highlight the platform’s challenges in competing with the established dominance of Twitter within the crypto industry. Twitter’s longstanding influence, engagement levels, and wide user base continue to solidify its position as the preferred platform for crypto enthusiasts.

Celsius Ex-Ceo Arrested

In a stunning turn of events, it has been reported that Alex Mashinsky, the former CEO of the now-defunct crypto lender Celsius, was arrested on the morning of July 13. This news sent shockwaves throughout the crypto community as it came on the same day that the United States Securities and Exchange Commission (SEC) filed a lawsuit against Celsius.

According to sources familiar with the matter cited by Bloomberg, Mashinsky’s arrest followed an extensive investigation into the collapse of the company. The crypto lender had filed for bankruptcy on July 14 of the previous year, and it was later revealed by the Commodity Futures Trading Commission (CFTC) that the former CEO had violated numerous U.S. regulations leading up to the company’s downfall in 2022.

The troubles for Celsius and its former CEO began in June of the previous year when the platform unexpectedly halted all withdrawals. This raised suspicions, and on June 16, 2022, securities regulators from five different U.S. states launched an investigation into Celsius. Within a month, the platform was forced to file for bankruptcy. Although Celsius was undoubtedly impacted by the broader crypto turmoil, including the collapse of the Terra-Luna ecosystem and crypto hedge fund Three Arrow Capital, the CFTC’s investigation uncovered evidence of multiple banking law violations and the misleading and deceptive practices employed by Celsius and its former CEO.

During the bull run of 2021, the Celsius cryptocurrency lending platform gained significant momentum, thanks in part to the ongoing pandemic. Offering attractive interest rates on cryptocurrency deposits, some of which reached double digits, the platform presented itself as a safer alternative to traditional banking services. However, the demise of Terra’s algorithmic stablecoin UST and a subsequent slump in the cryptocurrency market had dire consequences for the business.

The arrest of Mashinsky and the lawsuit against Celsius occur just months after the SEC filed similar lawsuits against prominent crypto exchanges Binance and Coinbase. These legal actions reflect the increasing scrutiny and regulatory measures being imposed on the crypto industry, underscoring the need for transparency and compliance to ensure the stability and integrity of the market.

Judge Rules Ripple’s XRP Sales and Distributions Not an Investment Contract

In a significant ruling, Judge Analisa Torres has determined that the sale of XRP by Ripple to the general public and its distributions of the token do not qualify as an offer and sale of an investment contract. This ruling sheds light on the legal status of XRP and its implications for Ripple and the cryptocurrency market as a whole.

Understanding the Court’s Decision

The court’s decision focuses on two aspects: “Programmatic sales” and “Other Distributions.” Programmatic sales refer to the offering of XRP to public buyers, while Other Distributions involve the distribution of XRP for free to individuals. Let’s delve into the court’s analysis of each of these scenarios.

Programmatic Sales: Public Buyers

The court determined that the sale of XRP to public buyers, commonly referred to as programmatic sales, does not meet the third prong of the Howey Test. The Howey Test is a legal framework used to determine whether an instrument qualifies as an investment contract. The third prong of the test examines whether the buyer’s expectation of profits is dependent on the efforts of others.

In the case of XRP programmatic sales, the court found that the public buyers could not have reasonably been aware of the statements and marketing campaigns connecting the token’s price performance to the company’s performance. Therefore, their expectation of profits was not contingent on the efforts of Ripple. Consequently, the court ruled that these sales do not constitute an investment contract.

Other Distributions: Free Allocations

The court also addressed the scenario of Other Distributions, where individuals received XRP for free. In this case, the court determined that the distribution of XRP without requiring any investment from the recipients fails the Howey test. The Howey test requires that the buyer invest money or assets with the expectation of profits.

Since the recipients of the free XRP did not put up any investment or assets to obtain the token, the court concluded that this distribution does not qualify as an investment contract.

Institutional Buyers: Investment Contracts

In contrast to the rulings on programmatic sales and other distributions, the court held that XRP sales to institutional buyers did constitute an offer and sale of an investment contract. The reason for this distinction lies in the level of sophistication and understanding of the institutional buyers.

The court noted that institutional buyers are considered “sophisticated” investors who possess the necessary knowledge and expertise to comprehend the relationship between XRP’s price and Ripple’s performance. Additionally, Ripple actively marketed and promoted the token to institutional buyers, creating a reasonable expectation of profit from their investments. As a result, the court concluded that XRP sales to institutional buyers qualify as investment contracts.

Implications and Ripple’s Marketing Strategies

Judge Analisa Torres’ ruling carries significant implications for Ripple and the wider cryptocurrency industry. By differentiating between sales to public buyers and institutional buyers, the court sets a precedent that may influence future legal determinations regarding digital assets.

Furthermore, this ruling sheds light on Ripple’s marketing strategies. While the court found that public buyers were unlikely to be aware of the connection between XRP’s price and Ripple’s performance, it emphasized that Ripple directly marketed and promoted the token to institutional buyers. This highlights the importance of transparency and clear communication in the promotion of digital assets, particularly when targeting sophisticated investors.

Final Thoughts

Judge Analisa Torres’ ruling clarifies the legal status of Ripple’s XRP sales and distributions. The court’s decision distinguishes between programmatic sales to the general public, other distributions of XRP, and sales to institutional buyers. While the former two do not constitute investment contracts, sales to institutional buyers were deemed to fall under that category. This ruling underscores the significance of informed investment decisions and the importance of clear communication between digital asset issuers and buyers. As the cryptocurrency landscape continues to evolve, legal clarity surrounding digital assets becomes increasingly crucial.